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M3 receptors can be found in exocrine glands and smooth muscles. M4 and M5 receptors are located largely from the CNS.Consequently, activation of 2-receptors on cholinergic nerve terminals in the gut wall inhibits acetylcholine release.Steps of methoctramine, a muscarinic M2 receptor antagonist, on muscarinic and nicotinic cholinoceptors in guinea-

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